H2N2V1, Main, Exploration, bibRecord, 000E72

Identification of broad binding class I HLA supertype epitopes to provide universal coverage of influenza A virus

Identifieur interne : 000E72 ( Main/Exploration ); précédent : 000E71; suivant : 000E73

Identification of broad binding class I HLA supertype epitopes to provide universal coverage of influenza A virus

Auteurs : Jeff Alexander [États-Unis] ; Pamuk Bilsel [États-Unis] ; Marie-France Del Guercio [États-Unis] ; Aleksandra Marinkovic-Petrovic [États-Unis] ; Scott Southwood [États-Unis] ; Stephani Stewart [États-Unis] ; Glenn Ishioka [États-Unis] ; Maya F. Kotturi ; Jason Botten [États-Unis] ; John Sidney ; Mark Newman [États-Unis] ; Alessandro Sette

Source :

Human immunology [ 0198-8859 ] ; 2010.

RBID : PMC:2856764

Abstract

Influenza virus remains a significant health concern with current circulating strains that affect millions each year plus the threat of newly emerging strains, such as swine-origin H1N1 and avian H5N1. Our hypothesis is that influenza-derived HLA-Class I-restricted epitopes can be identified for use as a reagent to monitor and quantitate human CD8⁺ T cell responses and for vaccine development to induce protective cellular immunity. Protein sequences from influenza A virus strains currently in circulation, agents of past pandemics and zoonotic infections of man were evaluated for sequences predicted to bind to alleles representative of the most frequent HLA-A and -B (Class I) types worldwide. Peptides that bound several different HLA molecules and were conserved among diverse influenza subtypes were tested for their capacity to recall influenza-specific immune responses using human donor PBMC. Accordingly, 28 different epitopes antigenic for human donor PBMC were identified and 25 were 100% conserved in the newly emerged swine-origin H1N1 strain. The epitope set defined herein should provide a reagent applicable to quantitate CD8⁺ T cell human responses irrespective of influenza subtype and HLA composition of the responding population. Additionally, these epitopes may be suitable for vaccine applications directed at the induction of cellular immunity.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856764

DOI: 10.1016/j.humimm.2010.02.014
PubMed: 20156506
PubMed Central: 2856764

Affiliations:

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Identification of broad binding class I HLA supertype epitopes to provide universal coverage of influenza A virus</title>
<author><name sortKey="Alexander, Jeff" sort="Alexander, Jeff" uniqKey="Alexander J" first="Jeff" last="Alexander">Jeff Alexander</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Pharmexa-Epimmune Inc., San Diego, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Pharmexa-Epimmune Inc., San Diego</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Bilsel, Pamuk" sort="Bilsel, Pamuk" uniqKey="Bilsel P" first="Pamuk" last="Bilsel">Pamuk Bilsel</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Pharmexa-Epimmune Inc., San Diego, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Pharmexa-Epimmune Inc., San Diego</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Del Guercio, Marie France" sort="Del Guercio, Marie France" uniqKey="Del Guercio M" first="Marie-France" last="Del Guercio">Marie-France Del Guercio</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Pharmexa-Epimmune Inc., San Diego, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Pharmexa-Epimmune Inc., San Diego</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Marinkovic Petrovic, Aleksandra" sort="Marinkovic Petrovic, Aleksandra" uniqKey="Marinkovic Petrovic A" first="Aleksandra" last="Marinkovic-Petrovic">Aleksandra Marinkovic-Petrovic</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Pharmexa-Epimmune Inc., San Diego, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Pharmexa-Epimmune Inc., San Diego</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Southwood, Scott" sort="Southwood, Scott" uniqKey="Southwood S" first="Scott" last="Southwood">Scott Southwood</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Pharmexa-Epimmune Inc., San Diego, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Pharmexa-Epimmune Inc., San Diego</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Stewart, Stephani" sort="Stewart, Stephani" uniqKey="Stewart S" first="Stephani" last="Stewart">Stephani Stewart</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Pharmexa-Epimmune Inc., San Diego, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Pharmexa-Epimmune Inc., San Diego</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ishioka, Glenn" sort="Ishioka, Glenn" uniqKey="Ishioka G" first="Glenn" last="Ishioka">Glenn Ishioka</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Pharmexa-Epimmune Inc., San Diego, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Pharmexa-Epimmune Inc., San Diego</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kotturi, Maya F" sort="Kotturi, Maya F" uniqKey="Kotturi M" first="Maya F." last="Kotturi">Maya F. Kotturi</name>
<affiliation><nlm:aff id="A2">Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, San Diego, Calfornia</nlm:aff>
<wicri:noCountry code="subfield">Calfornia</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Botten, Jason" sort="Botten, Jason" uniqKey="Botten J" first="Jason" last="Botten">Jason Botten</name>
<affiliation wicri:level="2"><nlm:aff id="A3">The University of Vermont College of Medicine, Burlington, Vermont</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Vermont</region>
</placeName>
<wicri:cityArea>The University of Vermont College of Medicine, Burlington</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Sidney, John" sort="Sidney, John" uniqKey="Sidney J" first="John" last="Sidney">John Sidney</name>
<affiliation><nlm:aff id="A2">Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, San Diego, Calfornia</nlm:aff>
<wicri:noCountry code="subfield">Calfornia</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Newman, Mark" sort="Newman, Mark" uniqKey="Newman M" first="Mark" last="Newman">Mark Newman</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Pharmexa-Epimmune Inc., San Diego, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Pharmexa-Epimmune Inc., San Diego</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Sette, Alessandro" sort="Sette, Alessandro" uniqKey="Sette A" first="Alessandro" last="Sette">Alessandro Sette</name>
<affiliation><nlm:aff id="A2">Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, San Diego, Calfornia</nlm:aff>
<wicri:noCountry code="subfield">Calfornia</wicri:noCountry>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">20156506</idno>
<idno type="pmc">2856764</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2856764</idno>
<idno type="RBID">PMC:2856764</idno>
<idno type="doi">10.1016/j.humimm.2010.02.014</idno>
<date when="2010">2010</date>
<idno type="wicri:Area/Pmc/Corpus">000553</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000553</idno>
<idno type="wicri:Area/Pmc/Curation">000553</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000553</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000940</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000940</idno>
<idno type="wicri:Area/Ncbi/Merge">000484</idno>
<idno type="wicri:Area/Ncbi/Curation">000484</idno>
<idno type="wicri:Area/Ncbi/Checkpoint">000484</idno>
<idno type="wicri:doubleKey">0198-8859:2010:Alexander J:identification:of:broad</idno>
<idno type="wicri:Area/Main/Merge">000E78</idno>
<idno type="wicri:Area/Main/Curation">000E72</idno>
<idno type="wicri:Area/Main/Exploration">000E72</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Identification of broad binding class I HLA supertype epitopes to provide universal coverage of influenza A virus</title>
<author><name sortKey="Alexander, Jeff" sort="Alexander, Jeff" uniqKey="Alexander J" first="Jeff" last="Alexander">Jeff Alexander</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Pharmexa-Epimmune Inc., San Diego, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Pharmexa-Epimmune Inc., San Diego</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Bilsel, Pamuk" sort="Bilsel, Pamuk" uniqKey="Bilsel P" first="Pamuk" last="Bilsel">Pamuk Bilsel</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Pharmexa-Epimmune Inc., San Diego, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Pharmexa-Epimmune Inc., San Diego</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Del Guercio, Marie France" sort="Del Guercio, Marie France" uniqKey="Del Guercio M" first="Marie-France" last="Del Guercio">Marie-France Del Guercio</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Pharmexa-Epimmune Inc., San Diego, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Pharmexa-Epimmune Inc., San Diego</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Marinkovic Petrovic, Aleksandra" sort="Marinkovic Petrovic, Aleksandra" uniqKey="Marinkovic Petrovic A" first="Aleksandra" last="Marinkovic-Petrovic">Aleksandra Marinkovic-Petrovic</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Pharmexa-Epimmune Inc., San Diego, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Pharmexa-Epimmune Inc., San Diego</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Southwood, Scott" sort="Southwood, Scott" uniqKey="Southwood S" first="Scott" last="Southwood">Scott Southwood</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Pharmexa-Epimmune Inc., San Diego, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Pharmexa-Epimmune Inc., San Diego</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Stewart, Stephani" sort="Stewart, Stephani" uniqKey="Stewart S" first="Stephani" last="Stewart">Stephani Stewart</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Pharmexa-Epimmune Inc., San Diego, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Pharmexa-Epimmune Inc., San Diego</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Ishioka, Glenn" sort="Ishioka, Glenn" uniqKey="Ishioka G" first="Glenn" last="Ishioka">Glenn Ishioka</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Pharmexa-Epimmune Inc., San Diego, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Pharmexa-Epimmune Inc., San Diego</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Kotturi, Maya F" sort="Kotturi, Maya F" uniqKey="Kotturi M" first="Maya F." last="Kotturi">Maya F. Kotturi</name>
<affiliation><nlm:aff id="A2">Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, San Diego, Calfornia</nlm:aff>
<wicri:noCountry code="subfield">Calfornia</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Botten, Jason" sort="Botten, Jason" uniqKey="Botten J" first="Jason" last="Botten">Jason Botten</name>
<affiliation wicri:level="2"><nlm:aff id="A3">The University of Vermont College of Medicine, Burlington, Vermont</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<placeName><region type="state">Vermont</region>
</placeName>
<wicri:cityArea>The University of Vermont College of Medicine, Burlington</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Sidney, John" sort="Sidney, John" uniqKey="Sidney J" first="John" last="Sidney">John Sidney</name>
<affiliation><nlm:aff id="A2">Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, San Diego, Calfornia</nlm:aff>
<wicri:noCountry code="subfield">Calfornia</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Newman, Mark" sort="Newman, Mark" uniqKey="Newman M" first="Mark" last="Newman">Mark Newman</name>
<affiliation wicri:level="2"><nlm:aff id="A1">Pharmexa-Epimmune Inc., San Diego, California</nlm:aff>
<country>États-Unis</country>
<placeName><region type="state">Californie</region>
</placeName>
<wicri:cityArea>Pharmexa-Epimmune Inc., San Diego</wicri:cityArea>
</affiliation>
</author>
<author><name sortKey="Sette, Alessandro" sort="Sette, Alessandro" uniqKey="Sette A" first="Alessandro" last="Sette">Alessandro Sette</name>
<affiliation><nlm:aff id="A2">Division of Vaccine Discovery, La Jolla Institute for Allergy and Immunology, San Diego, Calfornia</nlm:aff>
<wicri:noCountry code="subfield">Calfornia</wicri:noCountry>
</affiliation>
</author>
</analytic>
<series><title level="j">Human immunology</title>
<idno type="ISSN">0198-8859</idno>
<idno type="eISSN">1879-1166</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">Influenza virus remains a significant health concern with current circulating strains that affect millions each year plus the threat of newly emerging strains, such as swine-origin H1N1 and avian H5N1. Our hypothesis is that influenza-derived HLA-Class I-restricted epitopes can be identified for use as a reagent to monitor and quantitate human CD8<sup>+</sup>
 T cell responses and for vaccine development to induce protective cellular immunity. Protein sequences from influenza A virus strains currently in circulation, agents of past pandemics and zoonotic infections of man were evaluated for sequences predicted to bind to alleles representative of the most frequent HLA-A and -B (Class I) types worldwide. Peptides that bound several different HLA molecules and were conserved among diverse influenza subtypes were tested for their capacity to recall influenza-specific immune responses using human donor PBMC. Accordingly, 28 different epitopes antigenic for human donor PBMC were identified and 25 were 100% conserved in the newly emerged swine-origin H1N1 strain. The epitope set defined herein should provide a reagent applicable to quantitate CD8<sup>+</sup>
 T cell human responses irrespective of influenza subtype and HLA composition of the responding population. Additionally, these epitopes may be suitable for vaccine applications directed at the induction of cellular immunity.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Californie</li>
<li>Vermont</li>
</region>
</list>
<tree><noCountry><name sortKey="Kotturi, Maya F" sort="Kotturi, Maya F" uniqKey="Kotturi M" first="Maya F." last="Kotturi">Maya F. Kotturi</name>
<name sortKey="Sette, Alessandro" sort="Sette, Alessandro" uniqKey="Sette A" first="Alessandro" last="Sette">Alessandro Sette</name>
<name sortKey="Sidney, John" sort="Sidney, John" uniqKey="Sidney J" first="John" last="Sidney">John Sidney</name>
</noCountry>
<country name="États-Unis"><region name="Californie"><name sortKey="Alexander, Jeff" sort="Alexander, Jeff" uniqKey="Alexander J" first="Jeff" last="Alexander">Jeff Alexander</name>
</region>
<name sortKey="Bilsel, Pamuk" sort="Bilsel, Pamuk" uniqKey="Bilsel P" first="Pamuk" last="Bilsel">Pamuk Bilsel</name>
<name sortKey="Botten, Jason" sort="Botten, Jason" uniqKey="Botten J" first="Jason" last="Botten">Jason Botten</name>
<name sortKey="Del Guercio, Marie France" sort="Del Guercio, Marie France" uniqKey="Del Guercio M" first="Marie-France" last="Del Guercio">Marie-France Del Guercio</name>
<name sortKey="Ishioka, Glenn" sort="Ishioka, Glenn" uniqKey="Ishioka G" first="Glenn" last="Ishioka">Glenn Ishioka</name>
<name sortKey="Marinkovic Petrovic, Aleksandra" sort="Marinkovic Petrovic, Aleksandra" uniqKey="Marinkovic Petrovic A" first="Aleksandra" last="Marinkovic-Petrovic">Aleksandra Marinkovic-Petrovic</name>
<name sortKey="Newman, Mark" sort="Newman, Mark" uniqKey="Newman M" first="Mark" last="Newman">Mark Newman</name>
<name sortKey="Southwood, Scott" sort="Southwood, Scott" uniqKey="Southwood S" first="Scott" last="Southwood">Scott Southwood</name>
<name sortKey="Stewart, Stephani" sort="Stewart, Stephani" uniqKey="Stewart S" first="Stephani" last="Stewart">Stephani Stewart</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000E72 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000E72 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    H2N2V1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     PMC:2856764
   |texte=   Identification of broad binding class I HLA supertype epitopes to provide universal coverage of influenza A virus
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Main/Exploration/RBID.i   -Sk "pubmed:20156506" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd   \
       | NlmPubMed2Wicri -a H2N2V1

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 14 19:59:40 2020. Site generation: Thu Mar 25 15:38:26 2021

Serveur d'exploration H2N2

Identification of broad binding class I HLA supertype epitopes to provide universal coverage of influenza A virus

Identification of broad binding class I HLA supertype epitopes to provide universal coverage of influenza A virus

Source :

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki

	Serveur d'exploration H2N2
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.